Systems and Covid-19 contains papers presented at the 29th annual Safety-Critical Systems Symposium, held as an online virtual conference, in February 2021. The Symposium is for engineers, managers and academics in the field of system safety, across all industry sectors, so the papers making up this volume offer wide coverage of current safety topics and a blend of academic research and industrial experience. They include both recent developments in the field and discussion of open issues and questions. The topics covered in this volume include: Systems related to Covid-19, Internet of Things (IoT), Embedded Systems, Future Assurance, Software, Security Informed Safety and Human Factors and Safety Culture.