Our world is subject to dramatic change: the war in Ukraine, climate change, the threat of new infectious diseases and a new monarch in the UK. Life is having to adjust to this new normal of ‘shock’ changes. The new applications in system safety are no less profound: air taxis, offshore grids, remote air traffic control centres, UK space launches, virtual hospital wards, battery-electric trains, self-driving vehicles ... the list is extensive and growing. System safety practices and approaches must adapt to deal with these new applications and new technologies, especially in areas related to Artificial Intelligence and Machine Learning: object recognition and autonomous decision making, so crucial to new air, marine and road vehicles. Most of us now cannot understand the complexity inside systems which ensure safety, and we cannot sensibly be relied upon to take over if the systems fail suddenly. Hence systems need to be both fail-safe, with multiple levels of resilience, and to be able to explain their decisions. Justification is everything. Our horizons are expanding: everything we do now should be considered for impact on the environment, carbon release, wider human health and personal well-being.