Artificial Intelligence (AI) based technology is rapidly evolving and will have ma-jor implications for how humans and technology collaborate in workflows and operations. Dorthea Mathilde Kristin Vatn and Thor Myklebust use a traditional sociotechnical Human, Technology, Organization (HTO) framework to provide a theoretical introduction to the important implications for specialists working with Human Factors (HF) and suggest how the framework can be extended in the context of AI, highlighting three main implications for HF specialists in the age of AI.