Increasing autonomy of vehicle control features requires product integrity considerations that push the boundaries, and lie beyond the scope, of the present edition of the automotive functional safety standard ISO 26262. They include reliability, availability and cyber security as well as the safety-related aspects of Safety of the Intended Functionality (SOTIF), fail-operational functionality and the human-machine interaction. The purpose of this paper is to suggest a framework for the construction of an explicit product integrity assurance argument that caters for such considerations. The proposed framework builds on work previously developed by MISRA for arguing the achievement of functional safety within the scope of ISO 26262. The paper asserts that there is particular value in the creation of an explicit, holistic, product assurance argument for vehicles that feature autonomy as the considerations are inherently interrelated and extend beyond the scope of any one particular industry standard.