Since establishment of the SCSC in 1992 the world of safety-related computing and assurance has changede normously, but the fundamental principles of the approaches articulated in the first decade of the club remain valid. However, since 2000 the dramatic growth in the Internet and the changes to security threats exemplified by the attacks of 9/11 have changed the safety engineering world. The need for change is further illustrated by the impact of climate change, the growing importance of interdependencies and lessons from Fukushima accident emphasising the need for resilience. Innovation in technology, in particular the increasing autonomy of systems, also provides another driver for change. The paper therefore discusses these three challenges: security-informed safety, resilience and autonomy. But in addition there is a significant challenge in that we must not forget “normal business”: the challenge of continuing to apply what we know in a rigorous and competent manner in the light of organisational change, project pressures and resource limitations.